The Church of los Santos Ángeles Custodios started to be built when the land of the Chacra Quinta Alegre were acquired. In time the location was too small and a new larger chapel had to be built, leaving the previous one as the library. Thus, the Italian architect Ignazio Cremonesi is given the mission to carry out its remodeling, since he had participated in several other works in the Cathedral of Santiago.

Cremonesi stamps a romantic style seal to the façade of the church, finished off in a triangular pediment that is sustained by two pairs of Doric style columns and has both sides decorated with wall niches to later incorporate sculptural type figures that are crowned by two medium size bell towers, with a small lantern dome in the upper part of the roof, similar to the transformation made to the Cathedral.

The interior of the temple is built with a Latin cross layout of three naves. The central nave has the greatest height with a reduced cannon vault and a transept that has devotional altars on each corner. The entrance has a completely decorated dintel supported by columns, holding the main organ on the top.

The naves are separated by columns that are of a compound Ionic – Corinthian style with cornered wind spirals in their capitals that hold decorated semicircular arches. In the transept there are decorated scallops with paintings that accompany the larger disc that, previously, must have been opened to give way to the dome with a lantern. Today it is sealed.

The high altar is located in the apse of the central nave, with abundantly decorated walls with pictorial, sculptural and illuminating elements that underscore their beauty.